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A Guide to AMPK Activators
AMPK is deemed as the regulator that maintains cellular energy homeostasis that is the foundation for proper functioning of the body. In mammals, AMPK regulates the energy balance both on whole body level via response to the hormones and the brain and on cellular levels by way of sensing ATP/AMP and ATP/ADP ratio levels.
In the body, the most important energy molecule that is present is ATP. In essence, this is the starting point of cellular function. Now because of the reason that energy is used by cells, ATP breaks down into ADP that actually has got less potential for energy. ADP is then broken down to AMP which has contains the least energy potential among all 3. In reality, this is where AMPK is used; it senses the ratios of ATP/ADP/AMP and it tells the body if it requires more ADP so by that, it will be able to maintain optimal functions.
AMPK work on different processes via different mechanisms. Since the AMPK is considered as the master regulator for all functioning cells, it just makes sense. The effect that AMPK activation in the body depend on the complicated balance of factors and the signaling pathways. In the end, you are sure to reap plenty of benefits from improved AMPK activation like:
Anti aging – as we begin to age, AMPK activation begins to decline. Experts actually think that AMPK is one of the contributing factors of aging. AMPK is important because it helps in having adequate level of new mitochondria and promotes cellular renewal as well.
Anti inflammation – interestingly enough, AMPK activation can help in decreasing inflammation but it can be decreased as well by inflammation.
Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.
Basically, there are more and more nutritional products and herbal products/constituents discovered that are very effective in AMPK activator to which some include:
Number 1. AICAR – in AMP, AICAR is considered as its analog that is necessary for cellular use and storage similar to ATP. Since it’s the analog of AMP, AICAR can stimulate AMPK’s activity directly which can then improve muscle performance.
Number 2. ALA – ALA or in this case, Alpha Lipoic Acid is not just an effective antioxidant but also, a powerful AMPK activator. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.
Number 3. Green tea extract – this was actually discovered to help in activating AMPK by means of activating its upstream kinase.
Number 4. Berberine – because of its AMPK activation, berberine was discovered to carry the same anti diabetic effects as metformin.